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SkinCeuticals - Advanced skincare backed by science


Discoloration Defense


Discoloration Defense

Corrective serums

Discoloration Defense is awarded Best Brightening Serum for Extra Glow (Editor's Choice) in HerWorld Beauty Awards 2019. Correct stubborn dark spots, uneven skin tone for a brighter, more even complexion. Clinically proven to get rid of post-inflammatory hyperpigmentation (acne dark spots) by 80% in 12 weeks, and removes other pigmentation by 60% in 12 weeks. Results from 2 weeks.

SKIN TYPES: Normal, Oily, Combination, Dry,



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Product details

Formulated with 3% Topical TXA, 1% Kojic Acid, 5% Niacinamide and 5% HEPES. These 4 ingredients each target a different step of discoloration formation in the skin, to fade and prevent stubborn pigments from reoccurring. Discoloration Defense is a gentle, layerable, daily-use dark spot brightening serum.
  • A synergistic blend of anti-discoloration ingredients to reduce the appearance of dark spots of dark patches, improve brightness, and minimize the reoccurrence of discoloration (with continued use)
  • 60% average improvement in the appearance of stubborn brown patches, reduces acne spots by an average of 80% in 12 weeks.
  • Paraben-, fragrance-, silicone-, gluten-, and hydroquinone-free
  • Ideal at-home complement to professional skin discoloration treatments, such as chemical peels or laser treatments.

How to use

  • Apply 3-5 drops of this skin brightening serum to the face. Apply twice daily for best results.
  • If using in the morning, apply after a SkinCeuticals vitamin C serum and follow with a SkinCeuticals broad spectrum SPF 50+ sunscreen
  • Limit sun exposure while using this product
  • Do not use on irritated or broken skin. If irritation occurs, discontinue use

Visible results

In a 12-week clinical study, Discoloration Defense significantly improved the appearance of key skin discoloration markers:

  • 81% average improvement in the appearance of post-acne marks
  • 60% average improvement in the appearance of stubborn brown patches
  • 59% average improvement in the appearance of skin discoloration
  • 59% average improvement in the appearance of even skin tone

Pictures here represent average results of our clinical study. Individual results may vary.

See ProtocolProtocol: A 12-week, single-center, clinical study was conducted on 50 females, ages 25 to 60, Fitzpatrick I-IV, with mild to moderate facial skin discoloration, including stubborn dark spots, post-acne marks, and uneven skin tone. Discoloration Defense was applied to the face twice a day in conjunction with a sunscreen.  Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.


Science & proof

Dark spots and stubborn brown patches are common problems that almost everyone will face. Dark spots or stubborn brown spots/patches are areas of the skin with excess Melanin. Melanin is the pigment that gives our skin colour, but when the skin is inflammed, excess melanin is being produced in the skin, which emerges as darker coloured spots and makes the skin tone uneven. A complex, multi-step process takes place in the skin when we study how dark spots are formed:

Step 1: Inflammation Triggers - Sun/ UV exposure, acne, hormonal changes such as pregnancy are common triggers. They trigger inflammatory mediators, which activates the enzyme Tyrosinase in the skin’s lowest epidermal layers.
Step 2: Melanin Production - Tyrosinase enables Melanocytes in the skin to produce more Melanin. When the skin is inflammed, this produces excessive Melanin.
Step 3: Melanin Transfer - Excess melanin gets transferred through the layers of the skin over a few weeks.
Step 4: Emergence - Excess melanin emerges as dark spots or stubborn brown patches on the skin surface. These pigment deposits tend to be more difficult to be removed compared to other skin cells on the surface.

To address the 4 steps of pigmentation above, SkinCeuticals presents Discoloration Defense. This latest-generation dark spot corrector, using a combination of potent and proven anti-discoloration ingredients to address key types of skin discoloration. Each of the 4 active ingredients in this potent formulation targets a different step of the pigmentation cycle, thus correcting and preventing dark spots from its origin.


Key Ingredients


    Overall rating


    5 reviews



    • Location : Singapore
    • Age : 40-49 years


    Good for dark spots or dark patches

    I have just started using it 2 weeks back. No bad reaction. Dries very fast.Started to reduce some of my dark patches of the face, fading gradually.<br/>Will use the entire bottle and then will have a better idea if it works.<br/>On the whole I have been using Skin Ceuticals products for over a year and like most of them, they work. So I am thinking this should too. Hope this will be the best anti-dark spot serum that my skin will need.


    • Location : Singapore
    • Age : 30-39 years


    Good to remove dark spots

    I have been using this product for about 3 weeks and my skin does appear to be more even. I use in the morning and evening after CE ferulic. Very hopeful and excited to see how this can help reduce dark spots on my face after the 12 weeks.


    • Location : Singapore
    • Age : 40-49 years


    Promising Results

    I have been using this for 3 weeks now, in the morning after applying C E Ferulic and every night. I have laser to remove melasma on my cheeks and so far this product has seemed to help keep remove brown spots on my face. I've noticed the most improvement in reducing post-acne marks and also evening out my uneven skin tone. I have oily skin and a lot of serums make my skin look shiny but this one soaks right into my skin, which I love. Overall, I like this product and will continue to use it. Best brightening serum that I have used so far.


    • Location : Singapore
    • Age : 50-59 years


    Good serum to reduce hyperpigmentation

    I tried a sample of this on the advice of my derm, after I had my most recent laser to remove pigmentation. She said this would help maintain the results. I've been using the C E Ferulic for a few years along with the Physical Fusion SPF. Seems to be a good solution to remove post-inflammatory hyperpigmentation and reduce acne scars.


    • Location : Singapore
    • Age : 30-39 years


    Promising! Improve uneven skin tone

    Tried a sample. After only two weeks I am noticing dark spots fading. Pleasantly surprised!!! Figured it would take at least 4-6 weeks of use. Using four drops twice daily and will continue to do so!!! Very impressed so far! Hopeful this can get rid of pigmentation on my face and improve my uneven skin tone!

    More reviews

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