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SkinCeuticals - Advanced skincare backed by science


Discoloration Defense Serum Skin Discoloration Serum by SkinCeuticals
Discoloration Defense Serum


Discoloration Defense

Corrective serums

Daily dark spot corrector targets visible skin discoloration for brighter, more even-looking skin

SKIN TYPES: Normal, Oily, Combination, Dry,



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Product details

Discoloration Defense Serum is a layerable, daily-use dark spot corrector clinically proven to reduce the appearance of key types of skin discoloration, including hard-to-treat forms such as stubborn brown patches and post-acne marks.  Formulated with 1.8% tranexamic acid, 5% niacinamide, and 5% HEPES, this latest-generation formula improves the appearance of skin discoloration, brightens skin, and evens skin tone in as early as 2 weeks.
  • Features a synergistic blend of anti-discoloration ingredients to reduce the appearance of skin discoloration, improve brightness, and minimize the reoccurrence of discoloration (with continued use)
  • 41% average reduction in the appearance of stubborn brown patches
  • Fragrance-free
  • Ideal at-home complement to professional skin discoloration treatments, such as chemical peels or non-ablative laser; always consult with a physician for individual regimen recommendations

How to use

  • Twice daily, apply 3-5 drops of this skin discoloration serum to the face
  • If using in the morning, apply after a SkinCeuticals vitamin C serum and follow with a SkinCeuticals broad spectrum SPF 50+ sunscreen
  • Limit sun exposure while using this product

Visible results

In a 12-week clinical study, Discoloration Defense Serum significantly improved the appearance of key skin discoloration markers:

  • 41% average improvement in the appearance of stubborn brown patches
  • 46% average improvement in the appearance of skin discoloration
  • 71% average improvement in the appearance of post-acne marks
  • 35% average improvement in the appearance of even skin tone

See ProtocolProtocol: A 12-week, single-center, clinical study was conducted on 50 females, ages 25 to 60, Fitzpatrick I-IV, with mild to moderate facial skin discoloration, including stubborn dark spots, post-acne marks, and uneven skin tone. Discoloration Defense Serum was applied to the face twice a day in conjunction with a sunscreen.  Efficacy and tolerability evaluations were conducted at baseline and at weeks 2, 4, 8, and 12.


Science & proof

Everyday elements—including UV exposure, prescription drugs, and some professional treatments—can trigger production of melanin in the skin’s lowest epidermal layers.  This excess melanin rises to the surface of the skin, causing visible skin discoloration. Discoloration can manifest in a range of ways, including diffuse discoloration, post-acne marks, and stubborn brown patches on the cheekbones, forehead, and upper lip.

Discoloration Defense Serum is the latest-generation dark spot corrector, using a combination of potent and proven anti-discoloration ingredients—including new tranexamic acid—to address key types of skin discoloration.


Key Ingredients


    Overall rating


    5 reviews



    • Location : Singapore
    • Age : 40-49 years


    Good for dark spots or dark patches

    I have just started using it 2 weeks back. No bad reaction. Dries very fast.Started to reduce some of my dark patches of the face, fading gradually.<br/>Will use the entire bottle and then will have a better idea if it works.<br/>On the whole I have been using Skin Ceuticals products for over a year and like most of them, they work. So I am thinking this should too. Hope this will be the best anti-dark spot serum that my skin will need.


    • Location : Singapore
    • Age : 35-44 years


    Good to remove dark spots

    I have been using this product for about 3 weeks and my skin does appear to be more even. I use in the morning and evening after CE ferulic. Very hopeful and excited to see how this can help reduce dark spots on my face after the 12 weeks.


    • Location : Singapore
    • Age : 40-49 years


    Promising Results

    I have been using this for 3 weeks now, in the morning after applying C E Ferulic and every night. I have laser to remove melasma on my cheeks and so far this product has seemed to help keep remove brown spots on my face. I've noticed the most improvement in reducing post-acne marks and also evening out my uneven skin tone. I have oily skin and a lot of serums make my skin look shiny but this one soaks right into my skin, which I love. Overall, I like this product and will continue to use it. Best brightening serum that I have used so far.


    • Location : Singapore
    • Age : 50-59 years


    Good serum to reduce hyperpigmentation

    I tried a sample of this on the advice of my derm, after I had my most recent laser to remove pigmentation. She said this would help maintain the results. I've been using the C E Ferulic for a few years along with the Physical Fusion SPF. Seems to be a good solution to remove post-inflammatory hyperpigmentation and reduce acne scars.


    • Location : Singapore
    • Age : 30-39 years


    Promising! Improve uneven skin tone

    Tried a sample. After only two weeks I am noticing dark spots fading. Pleasantly surprised!!! Figured it would take at least 4-6 weeks of use. Using four drops twice daily and will continue to do so!!! Very impressed so far! Hopeful this can get rid of pigmentation on my face and improve my uneven skin tone!

    More reviews

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